One  drug missing from this  comprehensive list  is ethyl lactate. This was not investigated by the compilers of the list and it may be of some benefit. Ethyl lactate is metabolized by P.  acnes whose lipases convert  the Acids

 

•   5.0% formic acid (aqueous)

•   10% glycolic acid (aqueous)

•   1.5% iodoacetic acid in ethanolic solution

•   2.0% monochloracetic acid in water and propylene glycol

•   5.0% peracetic acid (aqeous)

•   5.0% periodic acid (aqueous)

•   5.0% phenol (aqueous)

•   7.5% p-iodophenol (ethanolic solution)

•   10% pyruvic acid (aqueous)

•   2.0% trichloracetic acid (aqueous) Surfactants and soaps

•   10% Ajax in aqueous suspension (household cleansing powder)

•   2.0% benzalkonium chloride (aqueous)

•   2.0% cetylpyridinium chloride (aqueous)

•   50% Ivory liquid detergent (aqueous)

•   5.0% sodium lauryl sulfate (aqueous)

•   5.0% toilet soaps (aqueous) Antimicrobials

•   5.0% chlorhexidine in ethanol:water (1:1) chlorine dioxide (aqueous) (1:1)

•   2.0% chloroxine in dimethylacetamide

•   2.0% chloroxine (ethanolic)

•   2.0% 8-hydroxyquinoline in ethanokpropylene glycol

•   2.0% hexachlorophene (alcoholic gel)

•   5.0% iodochlorhydroxyquin (vanishing cream)

•   2.0% isoniazid (aqueous)

•   2.0% p-chloro-xylenol (ethanolic)

•   5.0% pentachlorophenol (ethanolic) selenium sulfide (Selsen Suspension, Abbott)

•   3.0% 6-chloro-2-phenylphenol (ethanolic) (85:15)

•   2.0% sodium omadine (aqueous)

•   5.0% tetrachlorophenol (ethanolic)

•   2.0% tribomosalicylanilide (alcoholic gel)

•   2.0% trichlorocarbanilide (alcoholic gel)

•   5.0% zinc peroxide (vanishing cream)

•   2.0% zinc pyrithione  (alcoholic gel) Antibiotics

•   2.0% chloramphenicol (ethanolic)

•   2.0% kanamycin (aqueous)

•   2.0% minocycline  hydrochloride (vanishing cream)

•   2.0% neomycin sulfate (aqueous)

•   2.0% penicillin G  (aqueous)

•   2.0% rifampin in dimethyl  sulfoxide (DMSO)

•   2.0% tetracycline (alcoholic)

•   2.0% tetracycline base in dimethylacetamide

•   2.0% tetracycline hydrochloride (ethanolic)

•   2.0% tobramycin (aqueous) Miscellaneous acetone (5 times daily)

•   5.0% acetylcysteine (ethanolic)

•   5.0% acetylsalicylic acid (ethanolic)

•   10% aluminium chloride (aqueous)

•   0.3% colchicine in dimethylacetamide

•   10% dicholoronaphthoquinone in dimethylacetamide dimethylformamide

•   25% dimethyl sulfoxide (DMSO)

•   1.0% 5-fluorouracil (Fluoroplex, Herbert)

•   5.0% resorcinol (lotion)

•   10.0%  resorcinol (lotion)

•   3% 2-chloro-4-phenylphenol (ethanolic)

•   5.0% zinc sulfate (aqueous) Oral drugs  acetylcysteine (1.5 g/day)

•   chlorpheniramine  (20 mg/day, Chlor-Trimeton, Schering)

•   griseofulvin (1 g/day, Grifulvin V, McNeil)

•   isoniazid (300 mg/day)

•   penicillin V (1 g/day, Penicillin VK, Smith-Kline)

•   sulfadimethoxine (1 g/day,  Madribon, Roche)

•   sulfisoxazole (4 g/day, Gantrisin Preps, Roche)

•   Valium (20 mg/day, Roche) zinc sulfate (220 mg/day, Zincate, Canfield) Physical modalities

•   Massage (physical therapist, once daily)

•   PUVA (8-methoxypsoralen and UVA)

•   Sauna (facial, 5 min,  twice daily)

•   Sauna (facial, 5 min + 40% sodium chloride in vanishing

•   cream, twice daily)

•   Scrubs (polyester, polyethylene, pumice, borax, alumin)

•   UVA (thrice weekly,  20 J/cm2 per dose)

•   UVB (thrice weekly,  2 MEDs)

  Zonas tape (applied overnight, Johnson & Johnson) lactate to lactic acid, which has a pH of 3. At a pH of 3 bacteria have difficulty  in surviving, so ethyl lactate produces  a  sort of 'bacterial suicide'. In vivo studies show that it  suppresses by 1-2 log cycles skin surface P. acnes and produces a 40  per cent reduction in  skin surface free fatty acids. These  data  remain  to be confirmed.